TRIAD

Translational Biomarkers of Aging and Dementia

About

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The Translational Biomarkers in Aging and Dementia (TRIAD) cohort focuses on advanced personalized and preclinical dementia diagnosis. We study dementia markers and their progression from pre-symptomatic stages to the onset of the Alzheimer’s disease or other types of dementia. The TRIAD cohort assesses the trajectory of multiple imaging and fluid biomarkers in clinical populations and serves as a benchmark for testing novel biomarkers of dementia.

  • Launched in 2017, largest biomarker based study.
  • Large scale longitudinal cohort: more than 1000 people in the TRIAD registry.
  • Fluid biomarkers, PET scans, MRI scans, cognitive and neuropsychological assessments.
  • Population: Healthy young (HY) participants, cognitively unimpaired (CU), mild cognitive impairment (MCI), Alzheimer’s disease (AD) as well as other types of atypical AD and dementia.

Stats

Team

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Dr. Pedro Rosa-Neto MD, Ph.D
Director of the TRIAD cohort

and Associate Professor, McGill University, Montreal

Director of the McGill Center for Studies in Aging

Dr. Pedro Rosa-Neto MD (Federal University Rio Grande do Sul, Brazil), PhD (Aarhus University PET Centre, Denmark) is a professor of Neurology, Neurosurgery and Psychiatry at McGill University, affiliated to the Douglas Research Centre. He is also an adjunct professor of psychology at the Université du Québec à Montréal • (UQAM) and associated professor of Biomedical Science and Engineering (BMSE) at the Gwangju Institute of Science and Technology, South Korea He is a specialized in modelling dementia pathophysiological progression using imaging and fluid biomarkers. Dr. Rosa-Neto is the Director of the McGill Centre for Studies in Aging, a Fonds de Recherche Santé - Québec Senior Scholar, and vice chair of the CCNA team 2 'Inflammation and Trophic Factor deregulation in Alzheimer's disease. He is also committee member of the 4th and 5th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD). Dr. Rosa-Neto research is funded by Alzheimer's Association, Canadian Foundation for innervation (CFI), Fonds de Recherche Santé - Québec (FRQ-S), Canadian Institutes of Health Research (CIHR) and the Weston Brain Institute.

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Dr. Serge Gauthier, MD, FRCPC

Neurologist

Director, Alzheimer Disease Research Unit

Dr Serge Gauthier is Director of the Alzheimer's disease Research Unit at the McGill Centre for Studies in Aging, McGill University and a Professor at the University's Neurology and Neurosurgery, Psychiatry and Medicine Departments. He was formerly Clinical Investigator and Staff at the Montreal Neurological Hospital and Institute, Director of the McGill Centre for Studies in Ageing and Research Chair at the Canadian Institute for Health Research. His research interests include etiology and treatment of Alzheimer's disease and other related diagnosis and development of consensus guidelines on approval and use of antidementia drugs, and on the rights of persons with dementia to participate in research. Main publications are Clinical Diagnosis and Management of Alzheimer's Disease (2006), Alzheimer's Disease in Primary Care (1997) and Pharmacotherapy of Alzheimer's Disease (1998). His contributions to research include design and implementation of randomised clinical trials to establish the safety and efficacy of cholinesterase inhibitors, muscarinic agonists, and agents possibly modifying progression of Alzheimer’s disease and vascular dementia. He was a recipient of the Prix Galien Award in 1997 and has written and co-authored nearly 500 research articles.

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Mira Chamoun, Ph.D
Cohort Manager

Mira has a PhD in vision neurosciences and psychophysics from the Université de Montréal. She started as a postdoctoral fellow at the MCSA in June 2017. Mira will be working on projects axed on the studying of physical and biological markers associated with normal healthy aging and Alzheimer’s disease.

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Andrea Lessa Benedet, MSc
Biobank Manager

Currently, Andréa examines the impact of genetic markers of neuroinflammation on imaging outcomes of Alzheimer's disease. She is recipient of a Ciência sem Fronteiras (CsF) scholarship.

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Jenna Stevenson, BSc
Study Coordinator

I joined Dr. Rosa-Neto’s lab in January 2018 as a research assistant. In November 2018 I became the study coordinator. As the study coordinator of the TRIAD cohort my responsibilities include overseeing and guiding all research staff in various activities. I ensure that all appointments are scheduled in a timely manner to meet set milestones and deadlines. I plan and outline weekly clinical meetings and organize staff meetings to ensure maximal cooperation and productivity.

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Guylaine Gagné, R.N.
Senior Research Nurse

I joined the team in January 2018 and am the research nurse with Dr Pedro Rosa-Neto's team. I meet with all participants and explain the study by going through the consent form and answering all questions they may have. I am responsible for screening the participants by going through the inclusion criteria to ensure they are eligible. As the research nurse, I am responsible for collecting blood, urine and saliva samples from all participants. I remain in contact with participants every 6 months to updates our files and revise their medication lists.

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Nesrine Rahmouni, Bsc.
Research Assistant

At crossroads, I am responsible for the recruitment and enrollment of participants in the research cohort. This includes contacting and screening potential subjects for eligibility, scheduling of appointments, etc. I also assist the nurses and neuropsychologists in baseline and follow-up visits of participants in research studies (explanation of the protocol, consent forms, etc.) and I assist the research coordinator in meeting timelines. When needed, I work with students on wet lab experiments.

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Rie Maeda, MA.
Research Assistant

Started August 11th 2019
Research assistant responsible for:
o Ethics, Loris entry, Fukui/Japan project

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Alyssa Stevenson, Bsc.
Research Assistant

I joined the MCSA team in May of 2019. I am currently a Research Assistant within the Triad Cohort Study. My current responsibilities include creating participant profiles, inputting data, maintaining and transferring paper files onto the online database, and correction of conflicts. I also work alongside the research nurse to prepare the necessary materials for participant visits.

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Nina Poltronetti, Msc.
Psychometrician

I am the lead psychometrician on the research team and have been with the team since July 29th 2019.My responsibilities include conducting neuropsychological evaluations such as assessments of intelligence, attention, concentration, sensory-motor function, language, learning, and memory.
I am also responsible for preparing neuropsychological reports and participating in weekly clinical meetings. As the lead psychometrician, I am responsible for educating and supervising new research assistants interested in administering neuropsychological evaluations.

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Sherlaine Recinto, Bsc.
Research Assistant

I joined MCSA in October 2019 as a Research Assistant. I am currently part of the Triad Cohort Study research team. Some of my responsibilities include managing monthly recruitment and enrollment, scheduling and confirming participant appointments, explaining the study to participants in detail to ensure maximal understanding of participation as well as updating our online database.

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Ourdia Yahi, Msc.
Research Assistant

Data Privacy and Access

All the data collected under the TRIAD cohort is governed by the policies set by the Research Ethics Board Office of the McGill University, Montreal and the Douglas Research Center, Verdun. If you are a researcher and would like to access the TRIAD data for research purpose, please submit a data share request via our data share page.

Contact Us

If you would like to participate in our cohort (or to be part of our cohort) or if you have any inquiries.